This is coupled with the increased expression of transcriptional repressors Slug and Snail in primary human OECs, as well as increased Vimentin and MMPs expression which are all well-established to promote an invasive and metastatic phenotype in various cancers (Kessenbrock et al., 2010; Liu et al., 2010; Satelli and Li, 2011; Kidd et al., 2014; Basu et al., 2015). This evidence concerns the gene SNAI1 and cancer.