In addition, suppression of SSBP1 promoted triple-negative breast cancer cell metastasis through mtDNA depletion, which triggered calcineurin A-mediated mitochondrial retrograde signaling resulting in c-Rel/p50 translocation to the nucleus, increased levels of TGF-β and TGF-β-driven EMT (109). This evidence concerns the gene TGFB1 and triple-negative breast carcinoma.