SOD1 and amyotrophic lateral sclerosis: Because histamine receptor expression is known to change during development (42), and the microglial transcriptome is different in neonatal compared to adult mice (43, 44), and during ALS disease progression (45), it should be of interest to investigate in further studies if the effects of histamine obtained in neonatal SOD1-G93A microglia might be confirmed in adult microglia and moreover be dependent on the specific expression pattern of histaminergic receptors and enzymes.