SOD1 and amyotrophic lateral sclerosis: By analyzing the P2Y12 purinergic receptor expression known to be downregulated in SOD1-G93A microglia and ALS disease progression (29, 30), we showed that similar to the other anti-inflammatory markers, also P2Y12 receptor was significantly decreased by histamine in WT, but increased in SOD1-G93A microglia (Figure 6A).