As Cav-2 is not expressed in Cav-1−/− mice, we conclude that the observed effects in Cav-2−/− mice are not only due to the absence of Cav-2, supporting the idea that the balance of Cav-1 and Cav-2 activities is important for the expression of iNOS and the progress to sepsis (60). The gene discussed is CAV1; the disease is Sepsis.