Alternative therapeutic approaches based that inhibit TNF-α production have been successfully used for the pre-clinical and clinical treatment of chronic inflammatory diseases, particularly rheumatoid arthritis and temporomandibular joint disorders (Feldmann, 2002; Araújo et al., 2013; Freitas et al., 2016; Alves et al., 2017). Here, TNF is linked to temporomandibular joint disorder.