ADORA2A and nasopharyngeal carcinoma: Interestingly, stimulation of adenosine A2A receptors has been shown to rescue intracellular cholesterol accumulation and mitochondrial abnormalities in cell models of NPC (Ferrante et al., 2016), linking A2A agonism with the improvement of mitochondrial function and pathological phenotype of fibroblasts from NPC patients (Visentin et al., 2013).