The overall analysis showed that the MMP-2-1306 C/T polymorphism increased the risk of prostate cancer under CT vs. CC model (OR = 1.78, 95% CI = 1.33–2.38) and TT+CT vs. CC model (OR = 1.62, 95% CI = 1.24–2.12). This evidence concerns the gene MMP2 and prostate cancer.