In different mice models, Fibrillin-1 deficient, Fibulin-4 deficient and ANGII treated mice, the TGFβ inhibition prevented and reversed aortic aneurysm, making it a promising target for therapy (Habashi et al., 2006; Ramnath et al., 2015; Chen et al., 2016). This evidence concerns the gene AGT and aortic aneurysm.