Moreover, the intracellular localization and function of GPCRs in RPE cells was previously shown for the well-characterized GPCR ocular albinism type 1 (OA1), which is predominantly localized at the membranes of melanosomes, the organelles of pigment synthesis, and late endosomes/lysosomes. The gene discussed is GPR143; the disease is X-linked recessive ocular albinism.