Aberrant activation of Hh/Gli signaling has been linked to several types of cancer, including those of the skin, brain, lungs, prostate, gastrointestinal tract, blood, and colon (Karhadkar et al., 2004; Clement et al., 2007; Stecca et al., 2007; Yuan et al., 2007; Xie, 2008; Varnat et al., 2009; Takezaki et al., 2011; Raz et al., 2012; Santini et al., 2012; Wang et al., 2012; Gonnissen et al., 2013; Pandolfi and Stecca, 2015). Here, GLI1 is linked to cancer.