Given our finding that retinal SIRT1 is decreased by aging and injury and the previous finding that SIRT1 can protect against optic nerve degeneration in glaucoma patients (Mimura et al., 2013), it is possible that SIRT1-activating drugs such as resveratrol may prevent or treat traumatic optic nerve injury as well as various optic neuropathies that involve oxidative stress (Zuo et al., 2013). This evidence concerns the gene SIRT1 and optic nerve disorder.