The role of contactin-2 in epilepsy is further suggested by studies in mice showing that while gross brain morphology of contactin-2 null mice appears to be indistinguishable from their wild-type littermates, contactin-2 null mice display spontaneous episodes of seizures despite demonstrating normal behavior and are more sensitive to convulsant stimuli than their wild-type littermates (Fukamauchi et al., 2001). The gene discussed is CNTN2; the disease is epilepsy.