NEGR1 and major depressive disorder: In Dark Agouti rats, NEGR1 is upregulated in response to venlafaxine (VLX), a serotonin and noradrenaline reuptake inhibitor used to treat major depressive disorder (MDD), suggesting that NEGR1 contributes to the VLX effect in MDD possibly by contributing to the establishment of new neuronal connections and changes in synaptic plasticity (Tamási et al., 2014).