In a study on late-onset Alzheimer’s disease, four SNPs (rs1629316, rs1547897, rs11222931, and rs11222932) in intron 1 of the Ntm gene (11q25) and one SNP (rs11223225) in intron 1 of the OBCAM gene (located on the same chromosome as Ntm < 80 kb apart) have been found to be associated with late-onset Alzheimer’s disease (Liu et al., 2007). This evidence concerns the gene OPCML and Alzheimer disease.