AD is characterized by deposition of beta-amyloid peptides (Abeta), phosphorylated tau protein and frequent alpha-synuclein deposits; LBD show alpha-synuclein positive deposits, while FTD present tau-positive and tau-negative, ubiquitin- and TDP-43-positive inclusions (Jellinger, 2008). The gene discussed is MAPT; the disease is Alzheimer disease.