We observed significantly greater CRH gene expression in PTSD model animals [F(5, 18) = 7.763, p < 0.001, Partial Eta Squared = 0.68] including the positive control (6.56 ± 1.80) (P < 0.01) and PTSD+saline groups (5.45 ± 1.09) (P < 0.05) compared with the negative control group (1.34 ± 0.59). The gene discussed is CRH; the disease is post-traumatic stress disorder.