Oral administration of Aureobasidium pullulans enriched with branched β-glucans protected mice against a lethal challenge with influenza virus likely driven by the overexpression of retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) in macrophages linking virus sensor expression with influenza infection prevention [23]. Here, RIGI is linked to influenza.