NR1H4 and Alzheimer disease: In addition to the role in cholesterol elimination, bile acids exert effects on glucose and lipid metabolism via activation of bile acid receptors nuclear-farnesoid-X receptor (FXR) and G-protein-coupled plasma-membrane bound receptors (TGR5), directly linking bile acids with progression of AD with diabetes type II (Schilling 2016) or with cerebrovascular dysfunction (Humpel 2011b).