Proinflammatory cytokines such as IL-1β, IL-6, TNF-α, IFN-γ, IL-12, IL-17, and NO can be released by CD4 and CD8+ lymphocytes as well as by classically activated macrophages (CAMφs), which are important in the development of T1D. This evidence concerns the gene CD4 and type 1 diabetes mellitus.