CCR2 and psoriasis: Egawa et al. have also demonstrated that CCR2+ monocytes recruited at inflammatory sites had the potential to acquire an M2 phenotype in response to IL-4, thus exerting an anti-inflammatory function [41], while the expression of CCR2 (MCP-1/CCL2 protein receptor) of the peripheral monocytes of patients with psoriasis or atopic dermatitis was increased compared to that of healthy patients [42].