Among these, the four genes most strongly altered in schizophrenia were WFS1 (P = 1.8×10−7), angiotensinogen (AGT, P = 1.3×10−6), LRP4 (P = 2.7×10−6), and TNS2 (P = 9.3×10−4), all of which were increased in schizophrenia (Fig. 2c; Supplementary Table S3). Here, WFS1 is linked to schizophrenia.