NGF and rheumatoid arthritis: The top five canonical pathways among the 448 differentially expressed genes at FDR < 0.05 in the discovery cohort were the glucocorticoid receptor signaling pathway; pathway playing a role of macrophages, fibroblasts and endothelia cells in rheumatoid arthritis; actin cytoskeleton signaling pathway; NGF signaling pathway; and granzyme A signaling pathway (Table 2).