In the case of D2R-NR1 C1, normalizing the data to NR1 C1 content revealed that this association (F[2,69] = 3.62, p < 0.05) increases in both schizophrenics (LSD post-hoc test, p < 0.05) and depressives (LSD post-hoc test, p < 0.05) (Fig. 3d). This evidence concerns the gene DRD2 and major depressive disorder.