Human neurodegenerative tauopathies, which include a variety of diseases such as progressive supranuclear palsy (PSP), Pick’s disease and corticobasal degeneration, display progressive accumulation of hyper-phosphorylated tau protein and pathology together with cognitive impairments and synaptic loss in the absence of Aβ accumulation2,3. The gene discussed is MAPT; the disease is Cognitive impairment.