Only two studies have assessed inflammation in patients with DLB, both using cerebrospinal fluid (CSF), with one finding lower levels of IL-6 and the other finding no significant difference.10 11 No studies have examined inflammatory markers in the blood compared with controls, although a small exploratory study found that increased peripheral levels of IL-6 were associated with cognitive impairment in patients with DLB.12 The accessibility and practicality of using peripheral blood to monitor neuroinflammation in patients make this an attractive option. This evidence concerns the gene IL6 and Lewy body dementia.