MIF and arthritic joint disease: Co-expression of COXs and MIF is also implicated in various chronic inflammatory conditions such as sepsis, asthma, arthritis, dermatitis, atherosclerosis inflammatory, cell-mediated immunity, and innate immunity, as well as different functions of macrophages, such as tumorigenic activity, chemotaxis, and phagocytosis [6], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25].