CCN5 and breast cancer: CCN5/WISP2 has also been reported to be directly regulated by estrogen in the human breast cancer cell line MCF-7 and non-transformed human mammary epithelial cells, and is more highly expressed in a less-aggressive breast cancer cell line (MCF-7) compared with a highly aggressive (MDA-MB-231) (Banerjee and Banerjee 2012; Inadera 2003; Inadera et al. 2000; Zoubine et al. 2001).