CCN5 and obesity due to melanocortin 4 receptor deficiency: Similar to the findings by Hammarstedt et al. (Hammarstedt et al. 2013), the secretome of human adipose tissue was analyzed and showed that CCN5/WISP2 is a highly secreted adipokine that is downregulated in the visceral adipose tissue, compared with the subcutaneous adipose tissue, and correlated to obesity (Dahlman et al. 2012).