Although the upstream regulators of ADF/cofilin such as RAC, CDC42, PAK (Zhao et al., 2006), and LIMK have been reported to be diminished in AD brain and mouse models of AD (Barone et al., 2014), the consequence of this dysregulation on ADF/cofilin and the resulting F-actin destabilization (and altered treadmilling of actin) has not been investigated. The gene discussed is CFL1; the disease is Alzheimer disease.