Thus, despite the co-localization of p.tau with PrPTSE amyloid plaques in 87V-VM scrapie, and association with plaques described in other studies [19], [49], [50] results obtained in GSS-22 mice (overexpressor) and 101LL mice inoculated with recombinant PrP fibrils show that PrP-amyloidogenesis is not invariably associated with the formation of p.tau isoforms (Table 3). The gene discussed is PRNP; the disease is scrapie.