PRNP and amyloidosis: Although multiple PrP amyloid plaques were observed in the hippocampus and the corpus collosum of 101LL mice inoculated with Wt-rec or 101L-rec PrP fibrils (Fig. 6a, b), immunolabelling with antibodies AT8 and Thr.231 showed no p.tau in any area of the brain in both models (Fig. 6c, d).