However, it needs to be noted that our observations are not in agreement with other studies which found that CH25H KO mice show an alleviated course of EAE [19] and that WT mice expression of CH25H, CYP7B1, and the receptor itself is increased leading to autoimmunity and migration of reactive T cells into inflamed tissue [16]. The gene discussed is CH25H; the disease is Autoimmunity.