The IR per 10,000 PY of malignancies was lower in TNF inhibitor users (81/10,000 PY) compared with bDMARD nonusers (117/10,000 PY) in the BSRBR [20], and was 53.5/10,000 PY in bDMARD users and 74.1/10,000 PY in bDMARD nonusers from the Taiwan national database [22]. The gene discussed is TNF; the disease is cancer.