Recent study demonstrates that inhibition AICART activity of ATIC and a subsequent rise in intracellular 5-Aminoimidazole-4-carboxamide ribonucleotide (ZMP) plays a significant role in the anti-tumorigenic effects of the drug pemetrexed, which is used against non-small cell lung cancer [19, 20]. The gene discussed is ATIC; the disease is non-small cell lung carcinoma.