ATIC expression was markedly associated with serum AFP level (p = 0.0011), hepatitis status (p = 0.0352), vascular invasion (p = 0.0384), histologic grade (p = 0.0006) and Tumor node metastasis (TNM) stage (p = 0.0086) in HCC patients. The gene discussed is ATIC; the disease is hepatocellular carcinoma.