The results of the overall and subgroup analyses indicated that in the ATM gene, the rs189037 (−111G > A, −4519G > A), rs664677 (44831C > T, 49238C > T) and rs664143 (131,717 T > G) polymorphisms were significantly associated with lung cancer susceptibility (OR = 1.21, 95% CI = 1.04–1.39, P = 0.01; OR = 1.26, 95% CI = 1.06–1.49, P = 0.01; OR = 1.43, 95% CI = 1.15–1.78, P < 0.01). This evidence concerns the gene ATM and lung cancer.