SP-D levels in plasma were higher in patients with ARDS [median 20.8 ng/mL (IQR, 12.7–38.4); mean 26.9 ± 19.3 ng/mL] compared to those without ARDS [median 7.9 ng/mL (IQR, 4.0–17.0); mean 13.8 ± 17.2 ng/mL] (p < 0.01). The gene discussed is SFTPD; the disease is acute respiratory distress syndrome.