On the other hand, in a study by Determann et al., plasma SP-D levels at the initiation of mechanical ventilation were double in 16 patients with ARDS than in 20 patients without ARDS (275 ng/ml and 140 ng/ml, p = 0.09); however, this difference did not reach statistical significance, because that study was presumably underpowered [9]. The gene discussed is SFTPD; the disease is acute respiratory distress syndrome.