In this study, adult offspring with both maternal and paternal Holocaust-induced posttraumatic stress disorder (PTSD) demonstrated decreased levels of the 1F NR3C1 promoter methylation, while offspring with paternal PTSD only exhibited higher methylation levels of 1F NR3C1 promoter in the peripheral blood mononuclear cells compared to participants without parental Holocaust exposure. The gene discussed is NR3C1; the disease is post-traumatic stress disorder.