In the present study on 204 DLBCL patients, PD-L1 expression in tumor cells was an independent risk factor for OS (HR 1.40; 95% CI 1.61–10.23; P < 0.01), but not for PFS (HR 0.46; 95% CI 1.00–2.51; P = 0.05), in multivariate analysis. The gene discussed is CD274; the disease is neoplasm.