Curiel et al. [57] reported that tumor-infiltrating PD-L1-positive myeloid dendritic cells (MDCs) suppressed the induction of interferon-gamma (IFN-γ) in T cells and reduced IFN-γ-positive T cells, indicating that PD-L1-positive MDCs induce T-cell immune suppression in tumor microenvironment. The gene discussed is CD274; the disease is neoplasm.