CD274 and neoplasm: In multivariate analyses, age [hazard ratio (HR) 1.38; 95% confidence interval (CI) 1.69–9.40; P < 0.01], CR after first-line chemotherapy (HR − 1.54; 95% CI 0.09–0.49; P < 0.01), and PD-L1 expression in tumor cells (HR 1.40; 95% CI 1.61–10.23; P < 0.01) were independent risk factors for OS; stage (HR 0.69; 95% CI 1.23–3.23; P = 0.01) was an independent predictor for PFS (Table 3).