MCL has a highly unstable genome, which may lead to recurrent abnormalities, including loss of chromosome 1p, 8p, 9p (CDKN2A, CDKN2B), 9q, 11q (ATM), 13q14 and 17p (TP53) or addition of 3q, 8q (MYC), 10p (BMI1), 15q, and 18q. Here, TP53 is linked to mantle cell lymphoma.