Hsu NY studies have shown that p53R2 protein is closely related to the differentiation, stage and lymph node metastasis of NSCLCs and plays an important role in the early stages of recurrence [22],Okumura’s study revealed that p53R2 protein expression was associated with lymph node metastasis, depth of invasion, and clinical stage of esophageal squamous cell carcinoma. This evidence concerns the gene RRM2B and metastatic malignant neoplasm in the lymph nodes.