According to this system, specimens with ≥ 4 copies of EGFR signal in ≥ 40% cells, or ≥ 4 spots of gene clusters or ≥ 10% of tumor cells with ≥ 15 copies of EGFR signals or an EGFR/CEP7 ratio ≥ 2 were classified as positive for EGFR [129]. This evidence concerns the gene EGFR and neoplasm.