IHC:1. HER2 0 (≤ 10% invasive tumor cells with incomplete, faint membrane staining, or no staining)2. HER2 1+ (> 10% invasive tumor cells with faint and incomplete membrane staining);ISH:1. Single probe system with average number of HER2 copies < 4 signals per cell2. Dual probe system with HER2/CEP17 ratio of < 2.0 and average number of HER2 copies < 4 signals per cell. The gene discussed is ERBB2; the disease is neoplasm.