A different trial, comparing the combination of doxorubicin, cyclophosphamide and docetaxel (AC-T) with combination docetaxel, carboplatin and trastuzumab (ACH), as well as AC-T plus trastuzumab in patients with HER2 positive early stage breast cancer, showed a considerable clinical benefit with the use of trastuzumab. The gene discussed is ERBB2; the disease is breast cancer.