Higher serum MALAT-1 levels were found in OS pts compared to HC (≈1.16-fold increase, p < 0.001).Higher tissue MALAT-1 levels were found in tumour tissue in comparison to adjacent normal one (≈1.32-fold increase, p < 0.001).Higher MALAT-1 levels were associated with tumour size (p = 0.008) and distant metastasis (p < 0.0005).MALAT1 differentiated OS from HC: AUC = 0.834 [95% CI = 0.738–0.906], cut-off value = 3.68, sensitivity = 0.80; specificity = 0.73.High expression of MALAT1 was associated (KM compared with L-R) with poor S (p = 0.02) and PFS (p = 0.009). The gene discussed is MALAT1; the disease is neoplasm.