Circulating expression profile of 91H, a lncRNA located on the position of the H19/insulin-like growth factor 2(IGF2) locus, was investigated in the serum of OS patients and in healthy controls; interestingly, 91H overexpression was correlated with advanced clinical stage, chemotherapy after surgery and tumour size (when greater than 5 cm). This evidence concerns the gene IGF2 and neoplasm.