Higher plasma TUG1 levels were found in OS pts compared to HC (2.73-fold increase, p < 0.01);Higher tissue TUG1 levels were found in tumour tissue in comparison to adjacent normal one (3.46-fold increase, p < 0.01).Higher TUG1 levels in pts with disease progression or relapse compared with post-treatment pts (2.71-fold increase, p < 0.01).High expression of TUG1 is an independent prognostic factor of unfavorable survival (Cox regression) in OS pts with poor S (HR = 2.78 [95% CI = 1.29–6.00], p = 0.009) and PFS (HR = 1.81 [95% CI = 1.01–3.54], p = 0.037). The gene discussed is TUG1; the disease is neoplasm.