Different origins (embryonic midgut vs. hindgut), genetic and molecular alterations (BRAF mutations, chromosomal instability, microsatellite instability, and a CpG island methylator phenotype), invasion subtypes (mucinous vs. infiltrating histology), epidemiology, prognoses, recurrence patterns, and therapeutic effectiveness all suggest that the tumor biology differs between left- and right-sided CRCs [8, 23, 24]. This evidence concerns the gene BRAF and neoplasm.