In addition, although the statistical analysis was not provided, the previous study reported that the incidence of TP53 mutations of LCC-N was lower than ADC-S and NK-SQCC (LCC-N vs ADC-S + NK-SQCC = 0/2 vs 7/15, respectively), consistent with the results of our study. This evidence concerns the gene TP53 and leukoencephalopathy with calcifications and cysts.