These authors observed that adenocarcinoma with solid pattern (ADC-S) and nonkeratinizing squamous cell carcinoma (NK-SQCC), which were excluded from the 2015 WHO criteria of LCC, exhibited various gene mutations, including EGFR, KRAS, TP53 and other genes. This evidence concerns the gene TP53 and leukoencephalopathy with calcifications and cysts.