In the Gunnerson’s study, the [TIMP-2] × [IGFBP7] > 0.3 (ng/mL)2/1000 had a sensitivity of 92% for moderate or severe AKI within the next 12 hours, and was associated with approximately 7 times risk compared with the [TIMP-2] × [IGFBP7] ≤ 0.3 (ng/mL)2/1000 [19]. This evidence concerns the gene IGFBP7 and acute kidney injury.