As presented in Table 3, increased ZFAS1 expression was significantly associated with vascular invasion (OR = 2.26, 95% CI = 1.36–3.78, P = 0.002, Supplementary Figure 1), lymph node metastasis (OR = 2.98, 95% CI = 2.12–4.19, P < 0.001, Supplementary Figure 2) and advanced TNM stage (OR = 3.00, 95% CI = 2.18–4.12, P < 0.001, Supplementary Figure 3). The gene discussed is ZFAS1; the disease is metastatic malignant neoplasm in the lymph nodes.