HMGA2 and metastatic malignant neoplasm in the lymph nodes: As illustrated in Figure 2 and Figure 3, the results of the meta-analysis indicated that increased HMGA2 expression was significantly associated with TNM stage (RR = 1.54, 95% CI = 1.34-1.78, P < 0.00001, fixed-effects model), T stage (RR = 1.50, 95% CI = 1.18-1.90, P =0.0008, random-effects model), vascular invasion (RR = 1.69, 95% CI = 1.25-2.29, P = 0.0007, fixed-effects model), lymph node metastasis (RR = 1.50, 95% CI = 1.20-1.88, P = 0.0004, random-effects model), and lymphatic invasion (RR =1.25, 95% CI = 1.10-1.43, P = 0.001, fixed-effects model).