As shown in Figure 8, Sirtinol (10 nmol ×1 w, i.c.v.)increased in the expressions of GPR78 (Figure 8A), Chop (Figure 8B), and cleaved caspase-12 (Figure 8C) protein in the hippocampus of cotreatment with NaHS and CRS rats, which indicated that Sirtinol reverses the protective action of H2S on CRS-induced in hippocampal ER stress. Here, DDIT3 is linked to congenital rubella syndrome.