To confirm the mediatory role of Sirt1 in the inhibitory role of H2S in CRS-induced cognitive deficits, we further explored whether Sirtinol (10nmol ×1w, i.c.v.), a specific Sirt1 inhibitor, reverses the protection of H2S against cognitive dysfunction in CRS-exposed rats. The gene discussed is SIRT1; the disease is Cognitive impairment.