Genetic mutations of these enzymes lead to the lysosomal storage disorders Mucopolysaccharidosis VI (Maroteaux-Lamy-Disease), in which there is genetic mutation of ARSB, or Mucopolysaccharidosis IVA (Morquio A), in which there is genetic mutation of GALNS. The gene discussed is GALNS; the disease is mucopolysaccharidosis type 6.