TNF and cancer: Moreover, KEGG analysis showed that the main biochemical and signal transduction pathways were enriched in metabolic pathways, osteoclast differentiation, the TNF signaling pathway, the p53 signaling pathway, proteoglycans in cancer, pathways in cancer, the MAPK signaling pathway, vascular smooth muscle contraction, retinol metabolism, the PPAR signaling pathway, inflammatory mediator regulation of TRP channels, fatty acid elongation and arachidonic acid metabolism.