In the HMGB1 gene, the frequency of the A-C-G haplotype (corresponding to the rs1045411-rs3742305-rs2249825 variants) was significantly lower in IS patients than in controls (OR = 0.83, 95% CI: 0.70–0.98, P = 0.048) with a study power of 99.9%, and this haplotype was associated with a decreased risk of IS after adjusting for age, gender, smoking, hypertension, diabetes mellitus, and hyperlipidaemia when compared with the most common G-G-C haplotype. The gene discussed is HMGB1; the disease is Hypertension.