Amongst other findings, we observe a prototypical proteomic fingerprint of aerobic glycolysis (“Warburg effect”) in ccRCC tissue together with differential regulation of Xaa-Pro Aminopeptidases-1 and -2 (tumor-specific increase of XPNPEP1 with concomitant decrease of XPNPEP2). This evidence concerns the gene XPNPEP1 and nonpapillary renal cell carcinoma.