Both WNT2 and WNT5A are upregulated 2-5 fold in the CAFs of both CCD-18Co:HCT116 and CCD-18Co:HT29 co-culture 3D spheroids (Supplementary Table 3), mimicking increases in stromal-derived WNT signaling observed in CRC patient tumors [40]. Here, WNT5A is linked to colorectal carcinoma.