In this model, miR-483-5p recruits RNAi factors complex Ago1-Ago2 in a sequence-specific manner to the complementary target site of the P3 mRNA 5′UTR, and the P3 promoter of its host gene, IGF-II gene, which further results in enrichment of RNAP II and the activating histone marks at the P3 promoter, and then the transcription of P3 mRNA itself is activated in the nucleus of HCC cells. Here, AGO2 is linked to hepatocellular carcinoma.