Further, the report by Liu et al. showed that miR-483-5p could target the P3 mRNA 5′UTR of IGF-II gene rather than its promoter or promoter RNA, and in turn up-regulated its own transcription by enhancing the association of the RNA helicase DHX9 with the IGF2 transcript in MHH-ES-1 Ewing’s sarcoma cells [44]. The gene discussed is IGF2; the disease is Ewing sarcoma.